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Journal article

Targeting and silencing of rhodopsin by ectopic expression of the transcription factor KLF15

Abstract:

The genome-wide activity of transcription factors (TFs) on multiple regulatory elements precludes their use as gene-specific regulators. Here we show that ectopic expression of a TF in a cell-specific context can be used to silence the expression of a specific gene as a therapeutic approach to regulate gene expression in human disease. We selected the TF Krüppel-like factor 15 (KLF15) based on its putative ability to recognize a specific DNA sequence motif present in the rhodopsin (RHO) promo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci.insight.96560

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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
JCI Insight Journal website
Volume:
2
Issue:
24
Article number:
e96560
Publication date:
2017-12-21
Acceptance date:
2017-11-15
DOI:
ISSN:
2379-3708
Pmid:
29263295
Source identifiers:
812751
Language:
English
Keywords:
Pubs id:
pubs:812751
UUID:
uuid:aded3f7c-88f0-4651-8f60-a2d8cdb4daa9
Local pid:
pubs:812751
Deposit date:
2018-01-30

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