Journal article
Exome-wide association study of plasma lipids in >300,000 individuals.
- Abstract:
-
We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in mice showed lipid changes consistent with the human data. We also found that: (i) beta-thal...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 899.0KB)
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- Publisher copy:
- 10.1038/ng.3977
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Authors
Funding
Stanley J. Sarnoff Cardiovascular Research Foundation
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National Institute for Health Research
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Japanese Circulation Society
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Genetics Journal website
- Volume:
- 49
- Pages:
- 1758–1766
- Publication date:
- 2017-10-30
- Acceptance date:
- 2017-09-26
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- Pmid:
-
29083408
- Source identifiers:
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742114
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:742114
- UUID:
-
uuid:ae434285-544c-4b71-8418-ef2ff763c2df
- Local pid:
- pubs:742114
- Deposit date:
- 2017-11-09
Terms of use
- Copyright holder:
- Nature America, Inc
- Copyright date:
- 2017
- Notes:
- © 2017 Nature America, Inc., part of Springer Nature. All rights reserved.This is the accepted manuscript version of the article. The final version is available online from Nature Publishing Group at: http://dx.doi.org/10.1038/ng.3977
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