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Suppression of virus specific immune responses by IL-10 in acute dengue infection

Abstract:

BACKGROUND: Elevated IL-10 has been shown to be associated with severe dengue infection (DI). We proceeded to investigate the role of IL-10 in the pathogenesis of acute DI. MATERIALS AND METHODS: Ex vivo and cultured IFNγ ELISpot assays for dengue virus (DENV) NS3 protein and non dengue viral proteins were carried out in 26 patients with acute DI (16 with dengue haemorrhagic fever) and 12 healthy dengue seropositive individuals from Sri Lanka. DENV serotype specific (SS) responses were determ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Public Library of Science
Journal:
PLoS Neglected Tropical Diseases More from this journal
Volume:
7
Issue:
9
Pages:
e2409
Publication date:
2013-09-05
Acceptance date:
2013-07-24
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
Language:
English
Keywords:
UUID:
uuid:ae58ad8d-cdce-4b26-b68a-b8870a42c57c
Local pid:
pubs:429254
Source identifiers:
429254
Deposit date:
2013-11-16

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