Journal article
Suppression of virus specific immune responses by IL-10 in acute dengue infection
- Abstract:
-
BACKGROUND: Elevated IL-10 has been shown to be associated with severe dengue infection (DI). We proceeded to investigate the role of IL-10 in the pathogenesis of acute DI. MATERIALS AND METHODS: Ex vivo and cultured IFNγ ELISpot assays for dengue virus (DENV) NS3 protein and non dengue viral proteins were carried out in 26 patients with acute DI (16 with dengue haemorrhagic fever) and 12 healthy dengue seropositive individuals from Sri Lanka. DENV serotype specific (SS) responses were determ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 576.6KB)
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- Publisher copy:
- 10.1371/journal.pntd.0002409
Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Neglected Tropical Diseases Journal website
- Volume:
- 7
- Issue:
- 9
- Pages:
- e2409
- Publication date:
- 2013-09-05
- Acceptance date:
- 2013-07-24
- DOI:
- EISSN:
-
1935-2735
- ISSN:
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1935-2727
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:ae58ad8d-cdce-4b26-b68a-b8870a42c57c
- Local pid:
- pubs:429254
- Source identifiers:
-
429254
- Deposit date:
- 2013-11-16
Terms of use
- Copyright holder:
- Malavige et al
- Copyright date:
- 2013
- Notes:
- © 2013 Malavige et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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