Journal article icon

Journal article

HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor.

Abstract:

HIV-specific cytotoxic T lymphocytes (CTL) are important in controlling HIV replication, but the magnitude of the CTL response does not predict clinical outcome. In four donors with delayed disease progression we identified Vbeta13.2 T cell receptors (TCRs) with very similar and unusually long beta-chain complementarity determining region 3 (CDR3) regions in CTL specific for the immunodominant human histocompatibility leukocyte antigens (HLA)-B8-restricted human immunodeficiency virus-1 (HIV-...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1084/jem.20032044

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Expand authors...
Journal:
Journal of experimental medicine
Volume:
200
Issue:
12
Pages:
1547-1557
Publication date:
2004-12-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
28013

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP