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Thesis

Single cell analysis of breast cancer response to hypoxia

Abstract:

Triple-negative breast cancer (TNBC) is the subtype of breast cancer that has the worst clinical outcome due to the absence of specific targeting agents. TNBC is highly heterogeneous and within the tumour microenvironment, hypoxia emerges as a pivotal factor contributing to its aggressive biology. Solid tumours experience a fluctuating oxygen supply, leading to the formation of zones with prolonged oxygen deprivation.

There have been few studies describing the response to chronic h...

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Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
Oncology
Research group:
Buffa
Oxford college:
St Anne's College
Role:
Author
ORCID:
0000-0003-4414-384X

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
Oncology
Oxford college:
St Hugh's College
Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Sub department:
Surgical Sciences
Oxford college:
Linacre College
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
Oncology
Role:
Supervisor
Institution:
Bocconi University
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Oxford college:
Campion Hall
Role:
Examiner
More from this funder
Name:
European Research Council
Grant:
772970
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
DOI:
Language:
English
Keywords:
Subjects:
Deposit date:
2024-04-16

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