Journal article
Structural investigations of the inhibition of escherichia coli AmpC β-lactamase by diazabicyclooctanes
- Abstract:
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β-Lactam antibiotics are presently the most important treatments for infections by pathogenic Escherichia coli, but their use is increasingly compromised by β lactamases, including the chromosomally encoded class C AmpC serine-β lactamases (SBL). The diazabicyclooctane (DBO) avibactam is a potent AmpC inhibitor; the clinical success of avibactam combined with ceftazidime has stimulated efforts to optimise the DBO core. We report kinetic and structural studies, including four high resolution c...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 1.7MB)
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- Publisher copy:
- 10.1128/AAC.02073-20
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Authors
Funding
Bibliographic Details
- Publisher:
- American Society for Microbiology Publisher's website
- Journal:
- Antimicrobial Agents and Chemotherapy Journal website
- Volume:
- 65
- Issue:
- 2
- Article number:
- e02073-20
- Publication date:
- 2021-01-20
- Acceptance date:
- 2020-11-12
- DOI:
- EISSN:
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1098-6596
- ISSN:
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0066-4804
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1145544
- Local pid:
- pubs:1145544
- Deposit date:
- 2020-11-16
Terms of use
- Copyright holder:
- Lang et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 Lang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
- Licence:
- CC Attribution (CC BY)
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