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Distinct patterns of natural selection in the reverse transcriptase gene of HIV-1 in the presence and absence of antiretroviral therapy

Abstract:

The emergence of human immunodeficiency virus (HIV) drug-resistant mutations during antiretroviral therapy is explained by either the preexistence of low-frequency-resistant strains before the start of therapy or by the selection of unsuppressed resistant strains during therapy. We used pairwise and maximum likelihood analyses of the ratio of nonsynonymous to synonymous substitutions per site (dN/dS) to study the extent of positive selection in the reverse ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.virol.2004.04.004

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Institution:
University of São Paulo
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Institution:
University of São Paulo
Role:
Author
Bristol-Myers Squibb More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Virology Journal website
Volume:
325
Issue:
2
Pages:
181–191
Publication date:
2004-08-01
DOI:
ISSN:
0042-6822
Language:
English
Keywords:
Subjects:
UUID:
uuid:af65e225-3370-45ff-afcd-7f9207210272
Local pid:
ora:10696
Deposit date:
2015-03-23

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