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Using structural information to change the phosphotransfer specificity of a two-component chemotaxis signalling complex

Abstract:

Two-component signal transduction pathways comprising histidine protein kinases (HPKs) and their response regulators (RRs) are widely used to control bacterial responses to environmental challenges. Some bacteria have over 150 different two-component pathways, and the specificity of the phosphotransfer reactions within these systems is tightly controlled to prevent unwanted crosstalk. One of the best understood two-component signalling pathways is the chemotaxis pathway. Here, we present the ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pbio.1000306

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Research group:
Oxford Centre for Integrative Systems Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Oxford Centre for Integrative Systems Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Oxford Centre for Integrative Systems Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Oxford Centre for Integrative Systems Biology
Role:
Author
Biotechnology and Biological Sciences Research Council More from this funder
Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Biology Journal website
Volume:
8
Issue:
2
Article number:
e1000306
Publication date:
2010-02-01
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
Language:
English
Keywords:
Subjects:
UUID:
uuid:af6f99b9-4603-41f3-8428-acabc1268ecb
Local pid:
ora:4878
Deposit date:
2011-02-01

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