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Pallidal Deep Brain Stimulation Improves Higher Control of the Oculomotor System in Parkinson's Disease

Abstract:

The frontal cortex and basal ganglia form a set of parallel but mostly segregated circuits called cortico-basal ganglia loops. The oculomotor loop controls eye movements and can direct relatively simple movements, such as reflexive prosaccades, without external help but needs input from "higher" loops for more complex behaviors. The antisaccade task requires the dorsolateral prefrontal cortex, which is part of the prefrontal loop. Information flows from prefrontal to oculomotor circuits in th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1523/JNEUROSCI.2317-15.2015

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Oxford college:
Brasenose College
Role:
Author
ORCID:
0000-0002-1192-3834
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Oxford college:
Exeter, Exeter College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Oxford college:
St Antony's College
Role:
Author
ORCID:
0000-0002-7262-7297
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Publisher:
Society for Neuroscience Publisher's website
Journal:
Journal of Neuroscience Journal website
Volume:
35
Issue:
38
Pages:
13043-13052
Publication date:
2015-09-23
Acceptance date:
2015-08-09
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Pmid:
26400935
Source identifiers:
567831

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