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Journal article

The SET1 complex selects actively transcribed target genes via multivalent interaction with CpG island chromatin

Abstract:

Chromatin modifications and the promoter-associated epigenome are important for the regulation of gene expression. However, the mechanisms by which chromatin-modifying complexes are targeted to the appropriate gene promoters in vertebrates and how they influence gene expression have remained poorly defined. Here, using a combination of live-cell imaging and functional genomics, we discover that the vertebrate SET1 complex is targeted to actively transcribed gene promoters through CFP1, which ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2017.08.030

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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More from this funder
Funding agency for:
Feldmann, A
Grant:
110286/Z/15/Z
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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
20
Issue:
10
Pages:
2313-2327
Publication date:
2017-09-05
Acceptance date:
2017-08-06
DOI:
ISSN:
2211-1247
Pmid:
28877467
Language:
English
Keywords:
Pubs id:
pubs:725832
UUID:
uuid:b020cbd1-ebde-44ff-9ac5-2f24ddac3fe8
Local pid:
pubs:725832
Deposit date:
2017-09-19

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