Journal article
Molecular dynamics simulation of the M2 helices within the nicotinic acetylcholine receptor transmembrane domain: structure and collective motions
- Abstract:
-
Multiple nanosecond duration molecular dynamics (MD) simulations were performed on the transmembrane region of the Torpedo nicotinic acetylcholine receptor (nAChR) embedded within a bilayer mimetic octane slab. The M2 helices and M2-M3 loop regions were free to move whilst the outer (M1, M3, M4) helix bundle was backbone restrained. The M2 helices largely retain their hydrogen-bonding pattern throughout the simulation, with some distortions in the helical-end and loop regions. All of ...
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Authors
Contributors
Hung, Andrew
Sansom, Mark S. P.
Tai, Kaihsu
Bibliographic Details
- Publisher:
- Biophysical Society
- Journal:
- Biophysical Journal
- Issue:
- 88
- Publication date:
- 2005-01-01
Item Description
- Subjects:
- UUID:
-
uuid:b0bec0f7-182f-4a76-8b78-d0d9e9bbad3b
- Local pid:
- ora:697
- Source identifiers:
-
http://sers009b.sers.ox.ac.uk/archive/00001012/
- Deposit date:
- 2012-11-15
Terms of use
- Copyright date:
- 2005
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