Thesis
A semisynthetic protein nanoreactor for single-molecule chemistry
- Abstract:
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The covalent chemistry of individual reactants bound within a protein nanopore can be monitored by observing the ionic current flow through the pore, which acts as a nanoreactor responding to bond-making and bond-breaking events. However, chemistry investigated in this way has been largely confined to the reactions of thiolates, presented by the side chains of cysteine residues. The introduction of unnatural amino acids would provide a large variety of reactive side chains with which addit...
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Authors
Contributors
+ Bayley, H
Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Role:
Supervisor
Bibliographic Details
- Publication date:
- 2015
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:b0c61278-5483-44b7-a662-f079c0f2c23f
- Local pid:
- ora:12276
- Deposit date:
- 2015-09-28
Terms of use
- Copyright holder:
- Lee, J
- Copyright date:
- 2015
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