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A non-canonical voltage-sensing mechanism controls gating in K2P K(+) channels

Abstract:

Two-pore domain (K2P) K(+) channels are major regulators of excitability that endow cells with an outwardly rectifying background "leak" conductance. In some K2P channels, strong voltage-dependent activation has been observed, but the mechanism remains unresolved because they lack a canonical voltage-sensing domain. Here, we show voltage-dependent gating is common to most K2P channels and that this voltage sensitivity originates from the movement of three to four ions into the high electric f...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cell.2016.02.002

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Publisher:
Cell Press Publisher's website
Journal:
Cell Journal website
Volume:
164
Issue:
5
Pages:
937-949
Publication date:
2016-02-25
Acceptance date:
2016-01-29
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Source identifiers:
609078
Language:
English
Keywords:
Pubs id:
pubs:609078
UUID:
uuid:b0d7b333-6760-4c37-9daf-b1879fa074bc
Local pid:
pubs:609078
Deposit date:
2016-05-21

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