Journal article icon

Journal article

Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine

Abstract:

Vaccine development against the SARS-CoV-2 virus focuses on the principal target of the neutralizing immune response, the spike (S) glycoprotein. Adenovirus-vectored vaccines offer an effective platform for the delivery of viral antigen, but it is important for the generation of neutralizing antibodies that they produce appropriately processed and assembled viral antigen that mimics that observed on the SARS-CoV-2 virus. Here, we describe the structure, conformation, and glycosylation of the ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1021/acscentsci.1c00080

Authors


Expand authors...
Wellcome Trust More from this funder
Publisher:
American Chemical Society Publisher's website
Journal:
ACS Central Science Journal website
Volume:
7
Issue:
4
Pages:
594-602
Publication date:
2021-04-02
Acceptance date:
2021-04-02
DOI:
EISSN:
2374-7951
ISSN:
2374-7943
Pmid:
34056089
Language:
English
Keywords:
Pubs id:
1176250
Local pid:
pubs:1176250
Deposit date:
2021-07-14

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP