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Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers

Abstract:

Alzheimer’s disease (AD) is most commonly detected during old age, but the underlying neuropathologic changes likely appear decades earlier, especially among patients possessing genetic risk factors, such as the isoform E4 of the apolipoprotein E (ApoE4). In this study, we used magnetic resonance imaging (MRI) to assess default mode network (DMN) connectivity in 22 ApoE4 non-carriers and 14 matched ApoE4 carriers as well as white matter fractional anisotropy (FA) in 15 ApoE4 non-carriers and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s11682-012-9187-y

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Publisher:
Springer-Verlag Publisher's website
Journal:
Brain Imaging and Behavior Journal website
Volume:
7
Issue:
1
Pages:
60-67
Publication date:
2013-03-01
DOI:
EISSN:
1931-7565
ISSN:
1931-7557
Source identifiers:
446010
Language:
English
Keywords:
Subjects:
Pubs id:
pubs:446010
UUID:
uuid:b1a50f8d-7439-481e-8747-eaef78d6747b
Local pid:
pubs:446010
Deposit date:
2014-01-18

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