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Thesis

Novel culture of human islets with pancreatic matrix proteins

Abstract:

Background

The islet basement membrane (BM) is dissociated during the digestion phase of human islet isolation. A number of studies have demonstrated the beneficial effects conferred by extracellular matrix proteins (ECMP) of the BM on non-human islet function, but data are lacking regarding primary human islets. The aim of this study was to investigate the protective effects of supplementation of Connaught Medical Research Laboratories culture medium (CMRL) with Nidogen-1 (N...

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Division:
MSD
Department:
Surgical Sciences
Role:
Author

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Supervisor
Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford

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