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Characterization of DnaJB6: a molecular chaperone implicated in LGMD type 1D

Abstract:

To maintain protein homeostasis, life has developed highly conserved networks of molecular chaperones and degradation machinery to assist in protein synthesis, quality control, maintenance, localization and degradation. J-proteins (HSP40s) are a family of co-chaperones that specifically bind misfolded target proteins for the HSP70 chaperone machinery. DnaJB6 is a human J-protein shown to suppress aggregation of misfolded disease-related proteins such as huntingtin, aβ42 and α-synucle...

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Division:
MSD
Department:
Biochemistry
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
Language:
English
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UUID:
uuid:b1fca899-85a9-4a54-a436-e3166d3f078c
Deposit date:
2020-01-17

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