Journal article
Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation
- Abstract:
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T cell activation and especially trafficking of T cell receptor microclusters during immunological synapse formation are widely thought to rely on cytoskeletal remodeling. However, important details on the involvement of actin in the latter transport processes are missing. Using a suite of advanced optical microscopes to analyze resting and activated T cells, we show that, following contact formation with activating surfaces, these cells sequentially rearrange their cortical actin across the ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.8MB)
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- Publisher copy:
- 10.1126/sciadv.1603032
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Authors
Funding
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Advances Journal website
- Volume:
- 3
- Issue:
- 6
- Pages:
- e1603032
- Publication date:
- 2017-06-21
- Acceptance date:
- 2017-04-27
- DOI:
- ISSN:
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2375-2548
- Source identifiers:
-
707807
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:707807
- UUID:
-
uuid:b3220e1a-067a-47fa-945d-c59b3354ca75
- Local pid:
- pubs:707807
- Deposit date:
- 2017-07-20
Terms of use
- Copyright holder:
- © 2017 Fritzsche, et al
- Copyright date:
- 2017
- Notes:
- This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
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