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Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation

Abstract:

T cell activation and especially trafficking of T cell receptor microclusters during immunological synapse formation are widely thought to rely on cytoskeletal remodeling. However, important details on the involvement of actin in the latter transport processes are missing. Using a suite of advanced optical microscopes to analyze resting and activated T cells, we show that, following contact formation with activating surfaces, these cells sequentially rearrange their cortical actin across the ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/sciadv.1603032

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Institution:
University of Oxford
Oxford college:
Balliol College
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
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Funding agency for:
Fritzsche, M
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Funding agency for:
Davis, S
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Grant:
*Grant Number Example*
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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Advances Journal website
Volume:
3
Issue:
6
Pages:
e1603032
Publication date:
2017-06-21
Acceptance date:
2017-04-27
DOI:
ISSN:
2375-2548
Source identifiers:
707807
Language:
English
Keywords:
Pubs id:
pubs:707807
UUID:
uuid:b3220e1a-067a-47fa-945d-c59b3354ca75
Local pid:
pubs:707807
Deposit date:
2017-07-20

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