Building the Drosophila centriole: a structural investigation of the centriolar Proteins SAS-6, SAS-4 and Ana2

Thesis

The centriole is a complex cylindrical assembly found in the cells of ciliated eukaryotes. It serves two important roles in the cell: templating the growth of cilia, and forming the basis of the centrosome, which is the major microtubule organising centre in the cell. Cilia and centrosomes are involved in many cellular processes, from signalling to cell division and differentiation. As such, defects in centriole assembly can have downstream consequences on these processes and are linked to...

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Authors: Cottee, M

• Publication date: 2014
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: Structural Biology; X-ray Crystallography; Biochemistry; Drosophila; Centriole; Cell Biology
• Subjects: Structural biology; X-ray Crystallography; Biochemistry; Biophysical chemistry; Biology; Spectroscopy and molecular structure; Cell biology; Protein chemistry