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Thesis

Structural modelling of transmembrane domains

Abstract:

Membrane proteins represent about one third of all known vertebrate proteins and over half of the current drug targets. Knowledge of their three-dimensional (3D) structure is worth millions of pounds to the pharmaceutical industry. Yet experimental structure elucidation of membrane proteins is a slow and expensive process. In the absence of experimental data, computational modelling tools can be used to close the gap between the numbers of known protein sequences and structures. However, c...

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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Research group:
Oxford Protein Informatics Group
Oxford college:
Linacre College
Role:
Author

Contributors

Division:
MPLS
Department:
Statistics
Role:
Supervisor
Division:
MPLS
Department:
Statistics
Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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