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Thesis

Investigation into the epigenetic mechanisms involved in microglial activation in the animal model of multiple sclerosis

Abstract:

In patients with multiple sclerosis (MS), microglia become activated due to the autoimmune inflammatory response which is directed against the central nervous system (CNS). Following the first disease relapse, microglia remain activated and do not return to a resting state during remissions. Chronically-activated microglia release inflammatory mediators that cause CNS tissue damage, and as such, MS progression has been associated with widespread, chronic microglial activation that correlates ...

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Institution:
University of Oxford
Research group:
Prof. Lars Fugger's MS Research Group
Role:
Author

Contributors

Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:b4de0ef7-7588-4381-b099-9c8567805546
Local pid:
ora:11719
Deposit date:
2015-06-23

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