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The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators

Abstract:

LysR-type transcriptional regulators (LTTRs) form the largest family of bacteria regulators acting as both auto-repressors and activators of target promotors, controlling operons involved in a wide variety of cellular processes. The LTTR, CrgA, from the human pathogen Neisseria meningitidis, is unregulated during bacterial-host cell contact. Here, we report the crystal structures of both regulatory domain and full-length CrgA, the first of a novel subclass of LTTRs that form ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gkp445

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
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Institution:
University of Cambridge
Department:
Chemical Laboratory
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Bacterial Pathogenesis and Functional Genomics Group
Role:
Author
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Medical Research Council More from this funder
Biotechnology Biological Research Council More from this funder
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Funding agency for:
Sainsbury, S
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
37
Issue:
14
Pages:
4545-4558
Publication date:
2009-08-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Language:
English
Subjects:
UUID:
uuid:b50f391d-d916-494f-9500-a5d5c7846985
Local pid:
ora:3025
Deposit date:
2009-11-05

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