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Protein fold evolution on completed genomes: distinguishing between young and old folds

Abstract:

We review fold usage on completed genomes in order to explore protein structure evolution and assess the evolutionary relevance of current structural classification systems (SCOP and CATH). We assign folds on a set of 150 completed genomes using fold recognition methods (PSI-BLAST, SUPERFAMILY and Gene3D). The patterns of presence or absence of folds on genomes gives us insights into the relationships between folds and how we have arrived at the set of folds we see today. In particular, we de...

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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Research group:
Structural Bioinfomatics, Dr Charlotte Deane
Oxford college:
Jesus College
Role:
Author
More by this author
Division:
MPLS
Department:
Statistics
Role:
Author

Contributors

Division:
MPLS
Department:
Statistics
Role:
Supervisor
Publication date:
2007
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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