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Oxr1 is essential for protection against oxidative stress-induced neurodegeneration.

Abstract:

Oxidative stress is a common etiological feature of neurological disorders, although the pathways that govern defence against reactive oxygen species (ROS) in neurodegeneration remain unclear. We have identified the role of oxidation resistance 1 (Oxr1) as a vital protein that controls the sensitivity of neuronal cells to oxidative stress; mice lacking Oxr1 display cerebellar neurodegeneration, and neurons are less susceptible to exogenous stress when the gene is over-expressed. A conserved s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1002338

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
7
Issue:
10
Article number:
e1002338
Publication date:
2011-10-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Source identifiers:
193103
Language:
English
Keywords:
Pubs id:
pubs:193103
UUID:
uuid:b592d2e0-bb1a-43ab-8324-5140b3baf181
Local pid:
pubs:193103
Deposit date:
2012-12-19

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