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Specific synaptic input strengths determine the computational properties of excitation-inhibition integration in a sound localization circuit

Abstract:

During the computation of sound localization, neurons of the lateral superior olive (LSO) integrate synaptic excitation arising from the ipsilateral ear with inhibition from the contralateral ear. We characterized the functional connectivity of the inhibitory and excitatory inputs onto LSO neurons in terms of unitary synaptic strength and convergence. Unitary IPSCs can generate large conductances, although their strength varies over a 10-fold range in a given recording. By contrast, excitator...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1113/jp276012

Authors


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Role:
Author
ORCID:
0000-0003-4028-9294
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
ORCID:
0000-0003-1883-644X
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Role:
Author
ORCID:
0000-0001-9529-8839
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Role:
Author
ORCID:
0000-0002-6223-2830
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Funding agency for:
Zenke, F
Grant:
110124/Z/15/Z
Publisher:
John Wiley and Sons, Inc. Publisher's website
Journal:
Journal of Physiology Journal website
Volume:
596
Issue:
20
Pages:
4945-4967
Publication date:
2018-07-27
Acceptance date:
2018-07-18
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Pmid:
30051910
Source identifiers:
892014
Language:
English
Keywords:
Pubs id:
pubs:892014
UUID:
uuid:b5ba52dc-377d-4849-bd1a-7fb2712c7e62
Local pid:
pubs:892014
Deposit date:
2018-10-08

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