Journal article
Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.
- Abstract:
-
A defect in indoleamine 2,3-dioxygenase 1 (IDO1), which is responsible for immunoregulatory tryptophan catabolism, impairs development of immune tolerance to autoantigens in NOD mice, a model for human autoimmune type 1 diabetes (T1D). Whether IDO1 function is also defective in T1D is still unknown. We investigated IDO1 function in sera and peripheral blood mononuclear cells (PBMCs) from children with T1D and matched controls. These children were further included in a discovery study to ident...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1172/jci.insight.96244
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Authors
Funding
+ European Regional Development Fund
More from this funder
Funding agency for:
Carvalho, A
Grant:
IF/00735/2014
+ Fundação para a Ciência e Tecnologia
More from this funder
Funding agency for:
Cunha, C
Grant:
SFRH/BPD/96176/2013
+ European Research Council
More from this funder
Funding agency for:
Grohmann, U
Grant:
338954-DIDO
+ Associazione per l’Aiuto ai Giovani con Diabete Italia e dell’Umbria
More from this funder
Funding agency for:
Grohmann, U
Grant:
338954-DIDO
+ Fundação para a Ciência e Tecnologia
More from this funder
Funding agency for:
Carvalho, A
Grant:
IF/00735/2014
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation (ASCI) Publisher's website
- Journal:
- JCI insight Journal website
- Volume:
- 3
- Issue:
- 6
- Article number:
- e96244
- Publication date:
- 2018-03-22
- Acceptance date:
- 2018-02-13
- DOI:
- EISSN:
-
2379-3708
- Pmid:
-
29563329
- Source identifiers:
-
831860
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:831860
- UUID:
-
uuid:b5de47f0-51f3-42e6-ab55-40b6befebea3
- Local pid:
- pubs:831860
- Deposit date:
- 2018-04-04
Terms of use
- Copyright holder:
- © American Society for Clinical Investigation
- Copyright date:
- 2018
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