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Journal article

Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions

Abstract:

Integrins are the core constituents of cell–matrix adhesion complexes such as focal adhesions (FAs) and play key roles in physiology and disease. Integrins fluctuate between active and inactive conformations, yet whether the activity state influences the spatial organization of integrins within FAs has remained unclear. In this study, we address this question and also ask whether integrin activity may be regulated either independently for each integrin molecule or through locally coordinated ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1083/jcb.201707075

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Role:
Author
ORCID:
0000-0002-8348-3073
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Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Cell Biology Journal website
Volume:
217
Issue:
6
Pages:
1929-1940
Publication date:
2018-04-09
Acceptance date:
2018-03-26
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Pmid:
29632027
Source identifiers:
859109
Language:
English
Pubs id:
pubs:859109
UUID:
uuid:b6026bf1-603e-44ef-9f5d-02a3cefa8cf7
Local pid:
pubs:859109
Deposit date:
2019-07-08

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