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Journal article

Adult thymic medullary epithelium is maintained and regenerated by linage-restricted cells rather than bipotent progenitors

Abstract:

Medullary thymic epithelial cells (mTECs) play an essential role in establishing self-tolerance in T cells. mTECs originate from bipotent TEC progenitors that generate both mTECs and cortical TECs (cTECs), although mTEC-restricted progenitors also have been reported. Here, we report in vivo fate-mapping analysis of cells that transcribe β5t, a cTEC trait expressed in bipotent progenitors, during a given period in mice. We show that, in adult mice, most mTECs are derived from progenitors that ...

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Publication status:
In press
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2015.10.012
Publication website:
http://www.sciencedirect.com/science/article/pii/S2211124715011663

Authors


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Ministry of Education, Culture, Sports, Science and Technology More from this funder
Japan Society for the Promotion of Science More from this funder
Naito Foundation More from this funder
Publisher:
Cell Press Publisher's website
Journal:
Cell Reports
DOI:
ISSN:
2211-1247
UUID:
uuid:b66b036b-34b5-4032-9ecb-3897a9db8fcb
Deposit date:
2015-11-12

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