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Thesis

Inferring the fine-scale structure and evolution of recombination from high-throughput genome sequencing

Abstract:

In eukaryotes, recombination plays a critical role in both the production of viable gametes and as a population genetic process. Here, we are interested in studying recombination as it provides insight into a process that has shaped variation. To this end, we study the evolution of cross-over rates in chimpanzees and humans through two experiments.

Components of the recombination machinery are well described in yeast and C. elegans, but less so in other species. In humans, cross-ove...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Research group:
Medical Genomics and Statistics
Oxford college:
Queen's College
Role:
Author

Contributors

Role:
Supervisor
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Funding agency for:
Venn, O
Grant:
086786/Z/08/Z
More from this funder
Funding agency for:
Venn, O
Grant:
086786/Z/08/Z
More from this funder
Funding agency for:
Venn, O
Grant:
086786/Z/08/Z
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:b74f6706-a37d-4d71-975d-02e0f79ccdf1
Local pid:
ora:8184
Deposit date:
2014-03-11

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