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Thesis

Inferring the fine-scale structure and evolution of recombination from high-throughput genome sequencing

Abstract:

In eukaryotes, recombination plays a critical role in both the production of viable gametes and as a population genetic process. Here, we are interested in studying recombination as it provides insight into a process that has shaped variation. To this end, we study the evolution of cross-over rates in chimpanzees and humans through two experiments.

Components of the recombination machinery are well described in yeast and C. elegans, but less so in other species. In humans, cross-ove...

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Institution:
University of Oxford
Research group:
Medical Genomics and Statistics
Oxford college:
Queen's College, The
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
Role:
Author

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Supervisor
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Funding agency for:
Oliver Claude Venn
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Funding agency for:
Oliver Claude Venn
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:b74f6706-a37d-4d71-975d-02e0f79ccdf1
Local pid:
ora:8184

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