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Thesis

Stereoselective synthesis of disubstituted allylic alcohols by Wittig-Schlosser type reaction

Abstract:

The work presented in this thesis describes the development of reactions of β-lithiooxyphosphonium ylides and aldehydes to form disubstituted allylic alcohols in a regio- and stereoselective fashion.

Firstly, β-lithiooxyphosphonium ylides prepared from methylenetriphenyl-phosphorane and aldehydes, were shown to react with a second aldehyde to access allylic alcohols. The regio- and stereoselectivity in the formation of the double bond was shown to be greatly influenced by the nature ...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
DMH Group
Oxford college:
Corpus Christi College
Role:
Author

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Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Publication date:
2012
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:b7f2a982-f69b-4556-bd6b-b97347675bc8
Local pid:
ora:6631
Deposit date:
2012-12-20

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