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Action of incretins on the pancreatic alpha cell

Abstract:

T2D is a bihormonal disorder characterised by hypoinsulinaemia and hyperglucagonaemia. The incretin GLP-1 is therapeutically attractive as, in addition to augmenting glucose-stimulated insulin secretion, it is also able to suppress glucagon secretion from alpha cells. However, the mechanism by which GLP-1 is able to modulate glucagon secretion has not been fully established. The observation that the GLP-1 receptor is expressed at extremely low levels on alpha-cells has led some groups to p...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1142/9781783267378_0004

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
Publisher:
Imperial College Press Publisher's website
Pages:
79-97
Host title:
Incretin Biology - A Practical Guide: Glp-1 and Gip Physiology
Publication date:
2015-12-01
DOI:
Source identifiers:
656996
ISBN-10:
1783267364
ISBN-13:
9781783267361
Keywords:
Pubs id:
pubs:656996
UUID:
uuid:b8545e09-da95-4ece-9c37-27f458a9703e
Local pid:
pubs:656996
Deposit date:
2017-10-02

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