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Na⁺ ions as spatial intracellular messengers for co-ordinating Ca²⁺ signals during pH heterogeneity in cardiomyocytes.

Abstract:

AIMS: Contraction of the heart is regulated by electrically evoked Ca(2+) transients (CaTs). H(+) ions, the end products of metabolism, modulate CaTs through direct interactions with Ca(2+)-handling proteins and via Na(+)-mediated coupling between acid-extruding proteins (e.g. Na(+)/H(+) exchange, NHE1) and Na(+)/Ca(2+) exchange. Restricted H(+) diffusivity in cytoplasm predisposes pH-sensitive Ca(2+) signalling to becoming non-uniform, but the involvement of readily diffusible intracellular ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/cvr/cvu251

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More from this funder
Funding agency for:
Swietach, P
British Heart Foundation More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Cardiovascular research Journal website
Volume:
105
Issue:
2
Pages:
171-181
Publication date:
2015-02-01
Acceptance date:
2014-11-16
DOI:
EISSN:
1755-3245
ISSN:
0008-6363
Source identifiers:
500763
Language:
English
Keywords:
Pubs id:
pubs:500763
UUID:
uuid:b86d6f57-7e92-4497-93e1-940e77fc8b96
Local pid:
pubs:500763
Deposit date:
2015-01-12

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