Journal article
Na⁺ ions as spatial intracellular messengers for co-ordinating Ca²⁺ signals during pH heterogeneity in cardiomyocytes.
- Abstract:
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AIMS: Contraction of the heart is regulated by electrically evoked Ca(2+) transients (CaTs). H(+) ions, the end products of metabolism, modulate CaTs through direct interactions with Ca(2+)-handling proteins and via Na(+)-mediated coupling between acid-extruding proteins (e.g. Na(+)/H(+) exchange, NHE1) and Na(+)/Ca(2+) exchange. Restricted H(+) diffusivity in cytoplasm predisposes pH-sensitive Ca(2+) signalling to becoming non-uniform, but the involvement of readily diffusible intracellular ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.2MB)
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- Publisher copy:
- 10.1093/cvr/cvu251
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Authors
Funding
British Heart Foundation
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Cardiovascular research Journal website
- Volume:
- 105
- Issue:
- 2
- Pages:
- 171-181
- Publication date:
- 2015-02-01
- Acceptance date:
- 2014-11-16
- DOI:
- EISSN:
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1755-3245
- ISSN:
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0008-6363
- Source identifiers:
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500763
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:500763
- UUID:
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uuid:b86d6f57-7e92-4497-93e1-940e77fc8b96
- Local pid:
- pubs:500763
- Deposit date:
- 2015-01-12
Terms of use
- Copyright holder:
- Swietach et al
- Copyright date:
- 2015
- Notes:
- © The Author 2014. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Licence.
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