Journal article icon

Journal article

Single-molecule, super-resolution, and functional analysis of G protein-coupled receptor behavior within the T cell immunological synapse

Abstract:

A central process in immunity is the activation of T cells through interaction of T cell receptors (TCRs) with agonistic peptide-major histocompatibility complexes (pMHC) on the surface of antigen presenting cells (APCs). TCR-pMHC binding triggers the formation of an extensive contact between the two cells termed the immunological synapse, which acts as a platform for integration of multiple signals determining cellular outcomes, including those from multiple co-stimulatory/inhibitory recepto...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.3389/fcell.2020.608484

Authors


Expand authors...
More from this funder
Grant:
097813/Z/11/A
107375/Z/15/Z
100262/Z/12/Z
John Fell Fund More from this funder
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Cell and Developmental Biology Journal website
Volume:
8
Article number:
608484
Publication date:
2020-01-18
Acceptance date:
2020-12-21
DOI:
EISSN:
2296-634X
Pmid:
33537301
Language:
English
Keywords:
Pubs id:
1161399
Local pid:
pubs:1161399
Deposit date:
2021-06-30

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP