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Correlating glycoforms of DC-SIGN with stability using a combination of enzymatic digestion and ion mobility mass spectrometry

Abstract:

The immune scavenger protein DC‐SIGN interacts with glycosylated proteins and has a putative role in facilitating viral infection. How these recognition events take place with different viruses is not clear and the effects of glycosylation on the folding and stability of DC‐SIGN have not been reported. Herein, we report the development and application of a mass‐spectrometry‐based approach to both uncover and characterise the effects of O‐glycans on the stability of DC‐SIGN. We first quantify ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/anie.202005727

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Publisher:
Wiley Publisher's website
Journal:
Angewandte Chemie International Edition Journal website
Volume:
59
Issue:
36
Pages:
15690-15694
Publication date:
2020-07-07
Acceptance date:
2020-06-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Language:
English
Keywords:
Pubs id:
1130875
Local pid:
pubs:1130875
Deposit date:
2020-12-10

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