Journal article icon

Journal article

The interplay between prostate cancer genomics, metabolism, and the epigenome: perspectives and future prospects

Abstract:

Prostate cancer is a high-incidence cancer, often detected late in life. The prostate gland is an accessory gland that secretes citrate; an impaired citrate secretion reflects imbalances in the activity of enzymes in the TCA Cycle in mitochondria. Profiling studies on prostate tumours have identified significant metabolite, proteomic, and transcriptional modulations with an increased mitochondrial metabolic activity associated with localised prostate cancer. Here, we focus on the androgen rec...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.3389/fonc.2021.704353

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
Surgical Sciences
Oxford college:
Linacre College
Role:
Author
ORCID:
0000-0001-5347-5083
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Oncology Journal website
Volume:
11
Article number:
704353
Publication date:
2021-09-29
Acceptance date:
2021-08-31
DOI:
EISSN:
2234-943X
Language:
English
Keywords:
Pubs id:
1197738
Local pid:
pubs:1197738
Deposit date:
2021-10-01

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP