Journal article
β-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91–110 that recognise native PrPSc
- Abstract:
-
Prion diseases are associated with accumulation of strain-dependent biochemically distinct, disease-related isoforms (PrPSc) of host-encoded prion protein (PrPC). PrPSc is characterised by increased β-sheet content, detergent insolubility and protease resistance. Recombinant α-PrP adopts a PrPC-like conformation, while β-PrP conformationally resembles PrPSc, to these we raised 81 monoclonal antibodies in Prnp0/0 mice. The N-terminal residues 91–110 are highly immunogenic in β-PrP-immunised mi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1016/j.bbapap.2007.08.028
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Authors
Funding
Medical Research Council
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- BBA - Proteins and Proteomics Journal website
- Volume:
- 1774
- Issue:
- 11
- Pages:
- 1438-1450
- Publication date:
- 2007-09-06
- Acceptance date:
- 2007-08-17
- DOI:
- ISSN:
-
1570-9639
- Pmid:
-
17936697
Item Description
Terms of use
- Copyright holder:
- Published by Elsevier B.V.
- Copyright date:
- 2007
- Rights statement:
- Copyright © 2007 Published by Elsevier B.V.
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