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Journal article

β-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91–110 that recognise native PrPSc

Abstract:

Prion diseases are associated with accumulation of strain-dependent biochemically distinct, disease-related isoforms (PrPSc) of host-encoded prion protein (PrPC). PrPSc is characterised by increased β-sheet content, detergent insolubility and protease resistance. Recombinant α-PrP adopts a PrPC-like conformation, while β-PrP conformationally resembles PrPSc, to these we raised 81 monoclonal antibodies in Prnp0/0 mice. The N-terminal residues 91–110 are highly immunogenic in β-PrP-immunised mi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
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Medical Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
BBA - Proteins and Proteomics Journal website
Volume:
1774
Issue:
11
Pages:
1438-1450
Publication date:
2007-09-06
Acceptance date:
2007-08-17
DOI:
ISSN:
1570-9639
Pmid:
17936697
Language:
English
Keywords:
Pubs id:
1222652
Local pid:
pubs:1222652
Deposit date:
2022-07-03

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