Journal article
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
- Abstract:
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Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis of genome-wide association scans from 14 studies totalling 28,141 participants of European descent, resulting in identification of 954 SNPs distributed across nine loci that exceeded the threshold of genome-wide significance, five of which are novel. Overall, the common variants associated with se...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 486.1KB)
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- Publisher copy:
- 10.1371/journal.pgen.1000504
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Authors
Funding
Medical Research Council
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British Heart Foundation
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Barts and The London Charity
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GlaxoSmithKline
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Wellcome Trust
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS genetics Journal website
- Volume:
- 5
- Issue:
- 6
- Article number:
- e1000504
- Publication date:
- 2009-06-01
- DOI:
- EISSN:
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1553-7404
- ISSN:
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1553-7390
- Source identifiers:
-
18608
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:18608
- UUID:
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uuid:b9b0621a-0f93-4c65-8b8b-faa2d0d0e49f
- Local pid:
- pubs:18608
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Kolz et al
- Copyright date:
- 2009
- Notes:
- Copyright 2009 Kolz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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