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Journal article

IL-15 promotes polyfunctional NK cell responses to influenza by boosting IL-12 production

Abstract:

IL-15 is a key regulator of NK cell maintenance and proliferation and synergizes with other myeloid cell–derived cytokines to enhance NK cell effector function. At low concentrations, trans-presentation of IL-15 by dendritic cells can activate NK cells, whereas at higher concentrations it can act directly on NK cells, independently of accessory cells. In this study, we investigate the potential for IL-15 to boost responses to influenza virus by promoting accessory cell function. We find that ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1701614

Authors


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Role:
Author
ORCID:
0000-0002-4462-7484
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Jenner Institute
Department:
HC JENNER INSTITUTE
Role:
Author
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Role:
Author
ORCID:
0000-0003-3447-3570
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Role:
Author
ORCID:
0000-0002-8963-4768
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Grant:
Medical Research Council/Department for International Development Concordat Agreement (Grant G1000808 to E.M.R.
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Grant:
StudentshipinVaccine Research(toH.R.W.
C.M.N
Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
200
Issue:
8
Pages:
2738-2747
Publication date:
2018-04-09
Acceptance date:
2018-01-31
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
854039
Pubs id:
pubs:854039
UUID:
uuid:ba4e80af-0bc9-4869-80c7-5a48f4b174ae
Local pid:
pubs:854039
Deposit date:
2018-12-06

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