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Constitutive IDO1 expression in human tumors is driven by cyclooxygenase-2 and mediates intrinsic immune resistance

Abstract:

Tumors use various mechanisms to avoid immune destruction. Cyclooxygenase-2 (COX-2) expression may be a driver of immune suppression in melanoma, but the mechanisms involved remain elusive. Here, we show that COX-2 expression drives constitutive expression of indoleamine 2,3-dioxygenase 1 (IDO1) in human tumor cells. IDO1 is an immunosuppressive enzyme that degrades tryptophan. In a series of seven human tumor lines, constitutive IDO1 expression depends on COX-2 and prostaglandin E2 (PGE2), w...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/2326-6066.CIR-16-0400

Authors


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Ludwig Cancer Research More from this funder
Walloon Excellence in Life Sciences and Biotechnology More from this funder
Belgian Foundation Against Cancer More from this funder
Université catholique de Louvain More from this funder
de Duve Institute More from this funder
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Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Immunology Research Journal website
Volume:
5
Issue:
8
Pages:
695-709
Publication date:
2017-07-21
Acceptance date:
2017-06-30
DOI:
EISSN:
2326-6074
ISSN:
2326-6066
Source identifiers:
707825
Keywords:
Pubs id:
pubs:707825
UUID:
uuid:ba6a996e-24f2-4e82-8ef4-42dfd0fe7277
Local pid:
pubs:707825
Deposit date:
2017-07-12

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