Journal article
Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera
- Abstract:
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SARS-CoV-2 has caused over 2 million deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike. The scale of the pandemic and error-prone virus replication is leading to the appearance of mutant viruses and potentially escape from antibody responses. Variant B.1.1.7, now dominant in the UK, with increased transmission, harbors 9 amino acid changes in the spike, including N501Y in the ACE2 interacting surface. We examine the abilit...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 4.2MB)
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- Publisher copy:
- 10.1016/j.cell.2021.02.033
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Authors
Funding
John Fell Fund
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Bibliographic Details
- Publisher:
- Cell Press Publisher's website
- Journal:
- Cell Journal website
- Volume:
- 184
- Issue:
- 8
- Pages:
- 2201-2211.E7
- Publication date:
- 2021-02-18
- Acceptance date:
- 2021-02-13
- DOI:
- EISSN:
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1097-4172
- ISSN:
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0092-8674
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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1169283
- Local pid:
- pubs:1169283
- Deposit date:
- 2021-04-10
Terms of use
- Copyright holder:
- Supasa et al.
- Copyright date:
- 2021
- Rights statement:
- Copyright © 2021 The Author(s). This is an open access article published under CC BY 4.0.
- Licence:
- CC Attribution (CC BY)
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