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Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

Abstract:

SARS-CoV-2 has caused over 2 million deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike. The scale of the pandemic and error-prone virus replication is leading to the appearance of mutant viruses and potentially escape from antibody responses. Variant B.1.1.7, now dominant in the UK, with increased transmission, harbors 9 amino acid changes in the spike, including N501Y in the ACE2 interacting surface. We examine the abilit...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cell.2021.02.033

Authors


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John Fell Fund More from this funder
Publisher:
Cell Press Publisher's website
Journal:
Cell Journal website
Volume:
184
Issue:
8
Pages:
2201-2211.E7
Publication date:
2021-02-18
Acceptance date:
2021-02-13
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Language:
English
Keywords:
Pubs id:
1169283
Local pid:
pubs:1169283
Deposit date:
2021-04-10

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