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Aurora A promotes chromosome congression by activating the condensin-dependent pool of KIF4A

Abstract:

Aurora kinases create phosphorylation gradients within the spindle during prometaphase and anaphase, thereby locally regulating factors that promote spindle organization, chromosome condensation and movement, and cytokinesis. We show that one such factor is the kinesin KIF4A, which is present along the chromosome axes throughout mitosis and the central spindle in anaphase. These two pools of KIF4A depend on condensin I and PRC1, respectively. Previous work has shown KIF4A is activated by Auro...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1083/jcb.201905194

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Sir William Dunn School of Pathology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Sir William Dunn School of Pathology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Trinity College
Role:
Author
ORCID:
0000-0001-7518-253X
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Cell Biology Journal website
Volume:
219
Issue:
2
Article number:
e201905194
Publication date:
2019-12-27
Acceptance date:
2019-11-01
DOI:
EISSN:
1540-8140
ISSN:
0021-9525
Pmid:
31881080
Source identifiers:
1080184
Language:
English
Keywords:
Pubs id:
pubs:1080184
UUID:
uuid:bbb92b51-7ff0-4f9d-8dea-df1de3f46bb9
Local pid:
pubs:1080184
Deposit date:
2020-01-06

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