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Thesis

New approaches for improving the immunogenicity of modified vaccinia virus Ankara as a recombinant vaccine vector

Abstract:

The CD8+ T cell response to a transgenic antigen expressed in Modified Vaccinia virus Ankara (MVA) can be augmented with enhanced transgene expression. This thesis presents different approaches to increase transgene expression in MVA. The transgene used was the sequence of the pb9 murine malaria epitope, fused to Renilla luciferase gene, and then fused to a secretion leader sequence (tPA) at the N terminus. The insertion of Internal Ribosomal Entry Site (IRES) upstream of...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Oxford college:
Wolfson College
Role:
Author

Contributors

Division:
MSD
Department:
NDM
Role:
Supervisor
Division:
MSD
Department:
NDM
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:bbde86fd-ea8f-4e66-b260-f923d7e01e4b
Local pid:
ora:12098
Deposit date:
2015-08-07

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