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Highly trabeculated structure of the human endocardium underlies asymmetrical response to low-energy monophasic shocks

Abstract:

Novel low-energy defibrillation therapies are thought to be driven by virtual-electrodes (VEs), due to the interaction of applied monophasic electric shocks with fine-scale anatomical structures within the heart. Significant inter-species differences in the cardiac (micro)-anatomy exist, however, particularly with respect to the degree of endocardial trabeculations, which may underlie important differences in response to low-energy defibrillation protocols. Understanding the interaction of mo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1063/1.4999609

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Funding agency for:
Burton, R
Grant:
Sir Henry Dale Fellowship (109371/Z/15/Z
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Funding agency for:
Burton, R
Grant:
Sir Henry Dale Fellowship (109371/Z/15/Z
More from this funder
Grant:
National to the Centre of Excellence in Medical Engineering WT 088641/Z/09/Z
More from this funder
Grant:
National to the Centre of Excellence in Medical Engineering WT 088641/Z/09/Z
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Publisher:
AIP Publishing Publisher's website
Journal:
Chaos Journal website
Volume:
27
Issue:
9
Article number:
093913
Publication date:
2017-08-24
Acceptance date:
2017-08-03
DOI:
EISSN:
1089-7682
ISSN:
1054-1500
Source identifiers:
728853
Pubs id:
pubs:728853
UUID:
uuid:bd260f5d-2c99-401c-aad9-4b01f78c1e88
Local pid:
pubs:728853
Deposit date:
2017-09-22

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