Journal article
Phosphodiesterase 2A as a therapeutic target to restore cardiac neurotransmission during sympathetic hyperactivity
- Abstract:
-
Elevated levels of brain natriuretic peptide (BNP) are regarded as an early compensatory response to cardiac myocyte hypertrophy, although exogenously administered BNP shows poor clinical efficacy in heart failure and hypertension. We tested whether phosphodiesterase 2A (PDE2A), which regulates the action of BNP-activated cyclic guanosine monophosphate (cGMP), was directly involved in modulating Ca2+ handling from stellate ganglia (SG) neurons and cardiac norepinephrine (NE) release in rats a...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, pdf, 1018.7KB)
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- Publisher copy:
- 10.1172/jci.insight.98694
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Authors
Funding
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- JCI insight Journal website
- Volume:
- 3
- Issue:
- 9
- Pages:
- e98694
- Publication date:
- 2018-05-03
- Acceptance date:
- 2018-04-05
- DOI:
- ISSN:
-
2379-3708
- Pmid:
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29720569
- Source identifiers:
-
846111
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:846111
- UUID:
-
uuid:bd4da0a7-ebc3-47ab-b6cf-8efdc8a2f29b
- Local pid:
- pubs:846111
- Deposit date:
- 2018-05-09
Terms of use
- Copyright holder:
- American Society for Clinical Investigation
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 American Society for Clinical Investigation. This is the accepted manuscript version of the article. The final version is available online from the American Society for Clinical Investigation at: http://dx.doi.org/10.1172/jci.insight.98694
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