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A molecular mechanism of mitotic centrosome assembly in Drosophila.

Abstract:

Centrosomes comprise a pair of centrioles surrounded by pericentriolar material (PCM). The PCM expands dramatically as cells enter mitosis, but it is unclear how this occurs. In this study, we show that the centriole protein Asl initiates the recruitment of DSpd-2 and Cnn to mother centrioles; both proteins then assemble into co-dependent scaffold-like structures that spread outwards from the mother centriole and recruit most, if not all, other PCM components. In the absence of either DSpd-2 ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.03399

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Institution:
University of Oxford
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Role:
Author
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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
3
Issue:
August2014
Pages:
e03399
Publication date:
2014-01-01
Acceptance date:
2014-08-21
DOI:
EISSN:
2050-084X
ISSN:
2050-084X
Source identifiers:
482211
Language:
English
Keywords:
Pubs id:
pubs:482211
UUID:
uuid:bd6eb2b4-dde5-44f6-b8e5-64f90f93a6bb
Local pid:
pubs:482211
Deposit date:
2014-09-10

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