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Thesis

Biophysical characterization of protein-protein interactions with mass photometry

Alternative title:
In-vitro characterization of protein interactions with mass photometry
Abstract:

Interactions between biomolecules control the processes of life in health and their malfunction in disease, making their characterization and quantification essential. We first explore the capabilities of established methods for binding affinity measurements of protein-protein interactions and present mass photometry in this context. We explain that immobilization- and label-free analytical techniques are desirable because of their simplicity and minimal invasiveness, but that they struggl...

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Division:
MPLS
Department:
Physics
Sub department:
Theoretical Physics
Role:
Author

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Role:
Supervisor
Role:
Supervisor
ORCID:
0000-0003-0136-7704
Role:
Examiner
Role:
Examiner
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Programme:
Berrow Foundation Lord Florey Scholarship
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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