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Improved localisation for 2-hydroxyglutarate detection at 3T using long-TE semi-LASER

Abstract:

2-hydroxyglutarate (2-HG) has emerged as a biomarker of tumour cell IDH mutations that may enable the differential diagnosis of glioma patients. At 3 Tesla, detection of 2-HG with magnetic resonance spectroscopy is challenging because of metabolite signal overlap and a spectral pattern modulated by slice selection and chemical shift displacement. Using density matrix simulations and phanto experiments, an optimised semi-LASER scheme (TE = 110 ms) improves localisation of the 2-HG spin system ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.18383/j.tom.2016.00139

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
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Funding agency for:
Berrington, A
Grant:
Full-funded studentship
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Funding agency for:
Jezzard, P
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Funding agency for:
Emir, U
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Publisher:
Grapho Publications Publisher's website
Journal:
Tomography Journal website
Publication date:
2016-06-01
Acceptance date:
2016-05-13
DOI:
ISSN:
2379-1381
Source identifiers:
622370
Keywords:
Pubs id:
pubs:622370
UUID:
uuid:bdec3754-ca90-4c27-bdcd-52879260696e
Local pid:
pubs:622370
Deposit date:
2016-05-16

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