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Effect of CFIm25 knockout on RNA polymerase II transcription

Abstract:
Objectives Transcription of eukaryotic protein-coding genes by RNA polymerase II (pol II) is a highly regulated process. Most human genes have multiple poly(A) sites, which define different possible mRNA ends, suggesting the existence of mechanisms that regulate which poly(A) site is used. Poly(A) site selection may be mediated by cleavage factor I (CFIm), which is part of the cleavage and polyadenylation (CPA) complex. CFIm comprises CFIm25, CFIm59 and CFim68 subunits. It ha... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s13104-018-4006-1

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0002-4130-9050
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Oxford college:
Queens College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Oxford college:
Lady Margaret Hall
Role:
Author
Publisher:
BioMed Central Publisher's website
Journal:
BMC Research Notes Journal website
Volume:
894
Issue:
11
Publication date:
2018-12-14
Acceptance date:
2018-12-10
DOI:
EISSN:
1756-0500
Pmid:
30547832
Source identifiers:
954845
Language:
English
Keywords:
Pubs id:
pubs:954845
UUID:
uuid:be65551e-c8f0-40f5-b233-3001e254d9f1
Local pid:
pubs:954845
Deposit date:
2019-01-15

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