Thesis icon

Thesis

The role of compartmentalised cyclic nucleotides in pulmonary endothelial barrier function

Abstract:

The barrier function of the endothelium has been found to decrease in response to cyclic adenosine monophosphate (cAMP) elevations in the cellular cytosol, while it seems to be rescued by increasing cAMP concentrations at the membrane. This suggests that cAMP compartmentalisation may be a regulatory mechanism of barrier function.

Barrier dysfunction has been implicated in disease, including chronic obstructive pulmonary disease and oedema. It remains unknown whether cAMP compartment...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author

Contributors

Role:
Supervisor
Medical Research Council More from this funder
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
UUID:
uuid:bf3331e9-3bea-4543-b4f5-3c70c6e4bcfc
Deposit date:
2015-12-17

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP