Journal article icon

Journal article

Differential gene expression in macrophages from human atherosclerotic plaques shows convergence on pathways implicated by genome-wide association study risk variants

Abstract:

Objective

Plaque macrophages are intricately involved in atherogenesis and plaque destabilization. We sought to identify functional pathways in human plaque macrophages that are differentially regulated in respect of (1) plaque stability and (2) lipid content. We hypothesized that differentially regulated macrophage gene sets would relate to genome-wide association study variants associated with risk of acute complications of atherosclerosis.

Approach and Results

...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1161/ATVBAHA.118.311209

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Goel, A
More from this funder
Funding agency for:
Goel, A
More from this funder
Funding agency for:
Kyriakou, T
More from this funder
Funding agency for:
Biasiolli, L
Grant:
PG/15/74/31747
Expand funders...
Publisher:
American Heart Association Publisher's website
Journal:
Arteriosclerosis, Thrombosis, and Vascular Biology Journal website
Volume:
38
Issue:
1
Pages:
2718–2730
Publication date:
2018-09-06
Acceptance date:
2018-08-28
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
Source identifiers:
918782
Keywords:
Pubs id:
pubs:918782
UUID:
uuid:bf8212c0-0fcb-42f7-97da-502056a54541
Local pid:
pubs:918782
Deposit date:
2018-10-14

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP